Semaglutide Peptide
10mg · Lyophilized Powder · ≥98%
Semaglutide is a 31-amino acid GLP-1 receptor agonist based on the GLP-1(7-37) sequence with two key modifications: an Aib substitution at position 8 (protects against DPP-4 degradation) and a C-18 fatty diacid linker at position 26 (albumin binding for half-life extension). It has been studied in multiple large-scale clinical trial programs including SUSTAIN, PIONEER, and STEP, with over 20,000 total trial participants.
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Semaglutide
$44.99
Research Use Only
FOR RESEARCH USE ONLY. Products sold by Healthy Aminos are intended strictly for in-vitro research and laboratory use. Not for human or animal consumption. Not FDA approved. By purchasing from Healthy Aminos, the buyer acknowledges that these products are not intended to diagnose, treat, cure, or prevent any disease. All products are sold as reference standards and research chemicals only.
Compound Specifications
Research Context
Selective GLP-1 receptor agonist. Binds to GLP-1R to modulate glucose-dependent insulin secretion, glucagon suppression, and gastric emptying. The C-18 fatty diacid modification enables albumin binding for extended half-life (~7 days).
View published researchSemaglutide Published Research
Semaglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist with 94% structural homology to native human GLP-1. Developed through acylation modifications to extend half-life, it has been extensively studied in clinical trials involving thousands of participants and is the subject of over 1,500 published papers.
GLP-1 Receptor Pharmacology
Research has characterized semaglutide's binding affinity and activation kinetics at the GLP-1 receptor. Studies have examined its albumin-binding properties via the C-18 fatty diacid side chain, which extends its pharmacokinetic half-life. Published pharmacology research details its receptor residence time and downstream cAMP signaling in comparison to native GLP-1 and other GLP-1 receptor agonists.
References
Metabolic Research
Semaglutide has been studied in multiple large-scale clinical trial programs (SUSTAIN, STEP, PIONEER). Research published in the New England Journal of Medicine examined its effects on glycemic markers, body weight parameters, and cardiometabolic endpoints in controlled study populations. These trials enrolled thousands of participants across multiple countries.
References
Neurological Research
Published studies have investigated GLP-1 receptor agonists including semaglutide in neurological research models. Studies have examined GLP-1 receptor expression in brain tissue and investigated the effects of GLP-1 receptor activation on neuroinflammatory markers and neuroprotective pathways in preclinical models. Several clinical trials are ongoing in this research area.
References
The studies referenced above are presented for informational purposes only and do not constitute medical claims. All Healthy Aminos products are sold for research use only and are not intended for human consumption.
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FOR RESEARCH USE ONLY. Products sold by Healthy Aminos are intended strictly for in-vitro research and laboratory use. Not for human or animal consumption. Not FDA approved. By purchasing from Healthy Aminos, the buyer acknowledges that these products are not intended to diagnose, treat, cure, or prevent any disease. All products are sold as reference standards and research chemicals only.