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TB-500 5mg lyophilized peptide vial — Healthy Aminos, ≥98% purity
Healing & Recovery

TB-500 Peptide

5mg · Lyophilized Powder · ≥98%

TB-500 is a synthetic analog of Thymosin Beta-4 (Tβ4), a 43-amino acid peptide that occurs naturally in most mammalian tissues and cell types. Thymosin Beta-4 was first isolated from calf thymus tissue in the 1960s by Dr. Allan Goldstein at the National Institutes of Health. It operates primarily through its interaction with G-actin (globular actin), regulating actin polymerization which is fundamental to cell motility and migration. Published research has examined its effects in cardiac, dermal, corneal, and neurological models.

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Batch Information

Batch ID
Purity≥98%
FormLyophilized powder
Storage-20°C, protect from light
Third-party COA verified · 6-point testing protocol
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$54.99
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≥98% Purity Verified
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Research Use Only

TB-500

$54.99

Research Use Only

FOR RESEARCH USE ONLY. Products sold by Healthy Aminos are intended strictly for in-vitro research and laboratory use. Not for human or animal consumption. Not FDA approved. By purchasing from Healthy Aminos, the buyer acknowledges that these products are not intended to diagnose, treat, cure, or prevent any disease. All products are sold as reference standards and research chemicals only.

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Compound Specifications

Molecular Weight4921 Da
Molecular FormulaC212H350N56O78S
Amino Acid Sequence
Ac-SDKPDMAEIEKFDKSKLKKTETQEKNPLPSKETIEQEKQAGES
CAS Number77591-33-4
Synonyms
Thymosin Beta-4 Fragment, Tβ4
Research Applications
Cardiac tissue repairDermal wound healingCorneal repairNeurological researchCell migrationAnti-inflammatory

Research Context

Primary actin-sequestering peptide. Regulates actin polymerization through the LKKTET active domain (amino acids 17-22). Research has examined integrin-linked kinase (ILK) activation and downstream Akt/protein kinase B signaling.

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TB-500 Published Research

TB-500 is a synthetic analog of Thymosin Beta-4 (Tβ4), a 43-amino acid peptide naturally occurring in most mammalian tissues. Thymosin Beta-4 was first isolated from thymus tissue in the 1960s and has been the subject of substantial research regarding its role in cell migration, differentiation, and tissue repair processes.

Cell Migration and Actin Regulation

Thymosin Beta-4 is one of the primary intracellular G-actin sequestering peptides. Published research has demonstrated its critical role in actin polymerization dynamics, which underlies cell motility and migration. Studies in cell culture models showed that Tβ4 promotes endothelial cell migration, a key process studied in angiogenesis research.

References

Thymosin beta-4 promotes angiogenesis, wound healing, and hair follicle development — Ann N Y Acad Sci (2003). PMID: 12556448
Thymosin β4: actin regulation and more — Ann N Y Acad Sci (2007). PMID: 16412480

Cardiac Research

Several research groups have investigated Thymosin Beta-4 in cardiac models. Studies published in Nature examined Tβ4 in myocardial injury models in mice, investigating markers of cardiac function and tissue remodeling. Research has also examined Tβ4 in the context of epicardial progenitor cell activation and coronary vasculogenesis in developmental biology models.

References

Thymosin β4 activates integrin-linked kinase and promotes cardiac cell survival — Nature (2004). PMID: 15322537
Thymosin β4 induces adult epicardial progenitor mobilization — Nature (2011). PMID: 21336204

Dermal and Hair Follicle Research

Published research has examined Thymosin Beta-4 in dermal wound models and hair follicle biology. Studies in murine models investigated the role of Tβ4 in keratinocyte migration and hair follicle stem cell activation. Research published in PNAS characterized Tβ4-mediated signaling in hair growth cycle regulation.

References

Thymosin beta-4 stimulates wound healing — J Dermatol Sci (2003). PMID: 14660798
Thymosin beta-4 and hair growth — Ann N Y Acad Sci (2007). PMID: 17502601

The studies referenced above are presented for informational purposes only and do not constitute medical claims. All Healthy Aminos products are sold for research use only and are not intended for human consumption.

Frequently Asked Questions About TB-500

What is TB-500 peptide?
TB-500 is a research-grade peptide available from Healthy Aminos. TB-500 is a synthetic analog of Thymosin Beta-4 (Tβ4), a 43-amino acid peptide that occurs naturally in most mammalian tissues and cell types. Thymosin Beta-4 was first isolated from calf thymus tissue in the 1960s by Dr. Allan Goldstein at the National Institutes of Health. It operates primarily through its interaction with G-actin (globular actin), regulating actin polymerization which is fundamental to cell motility and migration. Published research has examined its effects in cardiac, dermal, corneal, and neurological models. It is supplied in lyophilized (freeze-dried) form for laboratory research use only.
What purity is Healthy Aminos TB-500?
Our TB-500 is verified at ≥98% purity via HPLC analysis. Each batch includes an independent third-party Certificate of Analysis (COA) with HPLC chromatogram and mass spectrometry confirmation.
How should I store TB-500?
TB-500 should be stored at -20°C, protect from light for long-term storage or 2-8°C for short-term use. Keep sealed, away from light and moisture. Lyophilized peptides maintain stability for 24+ months when stored properly.
Does Healthy Aminos TB-500 come with a COA?
Yes. Every batch of TB-500 ships with a batch-specific Certificate of Analysis including HPLC purity, mass spectrometry confirmation, endotoxin testing, sterility testing, and peptide content verification.
What is the molecular weight of TB-500?
TB-500 has a molecular weight of 4921 Da. Its molecular formula is C212H350N56O78S.
Is TB-500 legal to purchase?
TB-500 is sold as a Research Use Only (RUO) chemical reference standard. It is legal to purchase in the United States for legitimate scientific research. It is not approved by the FDA for any diagnostic, therapeutic, or clinical purpose.

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Research Use Only

FOR RESEARCH USE ONLY. Products sold by Healthy Aminos are intended strictly for in-vitro research and laboratory use. Not for human or animal consumption. Not FDA approved. By purchasing from Healthy Aminos, the buyer acknowledges that these products are not intended to diagnose, treat, cure, or prevent any disease. All products are sold as reference standards and research chemicals only.