MOTS-c Peptide
10mg · Lyophilized Powder · ≥98%
MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA Type-C) is a mitochondrial-derived peptide encoded by the mitochondrial genome. Discovered in 2015 by Dr. Changhan David Lee at USC, it is the first mitochondrial-encoded peptide shown to translocate to the nucleus and regulate nuclear gene expression — a novel retrograde signaling mechanism. Research has examined its role in AMPK activation and metabolic homeostasis.
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MOTS-c
$59.99
Research Use Only
FOR RESEARCH USE ONLY. Products sold by Healthy Aminos are intended strictly for in-vitro research and laboratory use. Not for human or animal consumption. Not FDA approved. By purchasing from Healthy Aminos, the buyer acknowledges that these products are not intended to diagnose, treat, cure, or prevent any disease. All products are sold as reference standards and research chemicals only.
Compound Specifications
Research Context
Activates AMPK signaling pathway. Modulates folate-methionine cycle and de novo purine biosynthesis. First mitochondrial-encoded peptide demonstrated to translocate to the nucleus and regulate nuclear gene expression.
View published researchMOTS-c Published Research
MOTS-c (Mitochondrial Open reading frame of the Twelve S rRNA type-c) is a mitochondrial-derived peptide (MDP) discovered in 2015 by Dr. Changhan Lee's laboratory at USC. It is encoded within the mitochondrial 12S rRNA gene and has been studied for its effects on metabolic regulation and exercise physiology.
Metabolic Regulation Research
Published research in Cell Metabolism characterized MOTS-c as a mitochondrial-derived signaling peptide that targets the folate-methionine cycle and AMPK pathway. Studies in mouse models investigated its effects on glucose homeostasis markers and insulin sensitivity parameters. Research examined its nuclear translocation in response to metabolic stress.
References
The studies referenced above are presented for informational purposes only and do not constitute medical claims. All Healthy Aminos products are sold for research use only and are not intended for human consumption.
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FOR RESEARCH USE ONLY. Products sold by Healthy Aminos are intended strictly for in-vitro research and laboratory use. Not for human or animal consumption. Not FDA approved. By purchasing from Healthy Aminos, the buyer acknowledges that these products are not intended to diagnose, treat, cure, or prevent any disease. All products are sold as reference standards and research chemicals only.