MOTS-c 10mg lyophilized peptide vial — Healthy Aminos, ≥99% purity

Anti-Aging & Longevity

MOTS-c Peptide

Name: MOTS-c Peptide (10mg)
Brand: Healthy Aminos
SKU: HA-MOTS-C
Availability: InStock

10mg · Lyophilized Powder · ≥99%

16-amino acid mitochondrial-derived peptide encoded within the 12S rRNA region, studied in metabolic homeostasis and AMPK pathway research.

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Batch Information

Batch ID

Purity≥99%

FormLyophilized powder

Storage-20°C, protect from light

Third-party COA verified · 6-point testing protocol

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$64.99

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≥99% Purity Verified

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Research Use Only

MOTS-c

$64.99

Research Use Only

FOR RESEARCH USE ONLY. Products sold by Healthy Aminos are intended strictly for in-vitro research and laboratory use. Not for human or animal consumption. Not FDA approved. By purchasing from Healthy Aminos, the buyer acknowledges that these products are not intended to diagnose, treat, cure, or prevent any disease. All products are sold as reference standards and research chemicals only.

Certificate of Analysis

Lab-Verified Purity

Independent Third-Party Laboratory

Jun 7, 2025 · HA202605-MOTS-C

Compound Specifications

Molecular Weight2174.69 Da

Molecular FormulaC₁₀₁H₁₅₂N₂₈O₂₂S₂

Amino Acid Sequence

Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg

CAS Number1627580-64-6

Synonyms

Mitochondrial-derived peptide, MOTS-c 16mer

Research Applications

Mitochondrial signalingAMPK activationMetabolic regulationExercise mimeticAging researchRetrograde signaling

Research Context

Activates AMPK signaling pathway. Modulates folate-methionine cycle and de novo purine biosynthesis. First mitochondrial-encoded peptide demonstrated to translocate to the nucleus and regulate nuclear gene expression.

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MOTS-c Published Research

MOTS-c (Mitochondrial Open reading frame of the Twelve S rRNA type-c) is a mitochondrial-derived peptide (MDP) discovered in 2015 by Dr. Changhan Lee's laboratory at USC. It is encoded within the mitochondrial 12S rRNA gene and has been studied for its effects on metabolic regulation and exercise physiology.

Metabolic Regulation Research

Published research in Cell Metabolism characterized MOTS-c as a mitochondrial-derived signaling peptide that targets the folate-methionine cycle and AMPK pathway. Studies in mouse models investigated its effects on glucose homeostasis markers and insulin sensitivity parameters. Research examined its nuclear translocation in response to metabolic stress.

References

MOTS-c is an exercise-induced mitochondrial-encoded regulator of metabolism — Cell Metab (2015). PMID: 25738459

MOTS-c translocates to the nucleus in response to metabolic stress — Cell Metab (2020). PMID: 33242418

The studies referenced above are presented for informational purposes only and do not constitute medical claims. All Healthy Aminos products are sold for research use only and are not intended for human consumption.

Frequently Asked Questions About MOTS-c

What is MOTS-c peptide?

MOTS-c is a research-grade peptide available from Healthy Aminos. 16-amino acid mitochondrial-derived peptide encoded within the 12S rRNA region, studied in metabolic homeostasis and AMPK pathway research. It is supplied in lyophilized (freeze-dried) form for laboratory research use only.

What purity is Healthy Aminos MOTS-c?

Our MOTS-c is verified at ≥99% purity via HPLC analysis. Each batch includes an independent third-party Certificate of Analysis (COA) with HPLC chromatogram and mass spectrometry confirmation.

How should I store MOTS-c?

MOTS-c should be stored at -20°C, protect from light for long-term storage or 2-8°C for short-term use. Keep sealed, away from light and moisture. Lyophilized peptides maintain stability for 24+ months when stored properly.

Does Healthy Aminos MOTS-c come with a COA?

Yes. Every batch of MOTS-c ships with a batch-specific Certificate of Analysis including HPLC purity, mass spectrometry confirmation, endotoxin testing, sterility testing, and peptide content verification.

What is the molecular weight of MOTS-c?

MOTS-c has a molecular weight of 2174.69 Da. Its molecular formula is C101H152N28O22S2.

Is MOTS-c legal to purchase?

MOTS-c is sold as a Research Use Only (RUO) chemical reference standard. It is legal to purchase in the United States for legitimate scientific research. It is not approved by the FDA for any diagnostic, therapeutic, or clinical purpose.