Peptide Bond
A peptide bond is a covalent amide linkage (-CO-NH-) formed between the alpha-carboxyl group of one amino acid and the alpha-amino group of the next, with the elimination of one water molecule (condensation reaction). This bond is the fundamental linkage in all peptides and proteins.
Peptide bonds are planar and partially rigid due to resonance between the carbonyl oxygen and the amide nitrogen, which gives the bond partial double-bond character. This restricts rotation and contributes to the defined three-dimensional structures that peptides adopt.
In solid-phase peptide synthesis (SPPS), each peptide bond is formed through a coupling reaction using activating reagents. The efficiency of each coupling step directly affects final product purity — for a 15-residue peptide like BPC-157, even 99% coupling efficiency per step yields only ~86% full-length product before purification.
All Healthy Aminos products are for research use only.
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Related Terms
Amino Acid
Organic molecules containing both an amino group (-NH2) and a carboxyl group (-COOH) that serve as the building blocks of peptides and proteins.
Amino Acid Sequence
The linear order of amino acid residues in a peptide or protein chain, written from N-terminus to C-terminus, which determines the molecule's identity and properties.
Solid-Phase Peptide Synthesis (SPPS)
The standard method for manufacturing synthetic peptides, where amino acids are sequentially coupled to a growing chain anchored to an insoluble resin.
Research Use Only
FOR RESEARCH USE ONLY. Products sold by Healthy Aminos are intended strictly for in-vitro research and laboratory use. Not for human or animal consumption. Not FDA approved. By purchasing from Healthy Aminos, the buyer acknowledges that these products are not intended to diagnose, treat, cure, or prevent any disease. All products are sold as reference standards and research chemicals only.