N-Terminus
The N-terminus (amino terminus) is the end of a peptide or protein chain bearing a free alpha-amino group (-NH2). By convention, peptide sequences are written starting from the N-terminal residue. For BPC-157, the N-terminal residue is glycine (Gly).
N-terminal modifications are common in synthetic research peptides. Acetylation (adding an acetyl group to the N-terminus) is frequently used to increase metabolic stability by preventing aminopeptidase degradation. Tesamorelin features a trans-3-hexenoic acid modification at its N-terminus, which extends its biological activity window in research models.
The N-terminus can also be important for receptor binding. In some peptides, the free amino group participates directly in receptor interactions, meaning N-terminal modifications can alter binding characteristics.
All Healthy Aminos products are for research use only.
Related Products
Related Terms
C-Terminus
The end of a peptide chain with a free carboxyl group (-COOH), conventionally written as the last residue in a sequence.
Amino Acid Sequence
The linear order of amino acid residues in a peptide or protein chain, written from N-terminus to C-terminus, which determines the molecule's identity and properties.
Acetylation
The addition of an acetyl group (CH3CO-) to the N-terminus of a peptide, commonly used to increase metabolic stability.
Research Use Only
FOR RESEARCH USE ONLY. Products sold by Healthy Aminos are intended strictly for in-vitro research and laboratory use. Not for human or animal consumption. Not FDA approved. By purchasing from Healthy Aminos, the buyer acknowledges that these products are not intended to diagnose, treat, cure, or prevent any disease. All products are sold as reference standards and research chemicals only.