Mitochondrial-Derived Peptide
Mitochondrial-derived peptides (MDPs) are a class of bioactive peptides encoded within the mitochondrial genome rather than the nuclear genome. This represents a form of retrograde signaling — mitochondria communicating with the nucleus and other cellular compartments.
MOTS-c is the most studied MDP in the Healthy Aminos catalog. Discovered by Lee et al. in 2015, it is encoded by the 12S rRNA gene and is the first mitochondrial-encoded peptide demonstrated to translocate to the nucleus and regulate nuclear gene expression. MOTS-c has been studied for AMPK pathway activation.
All Healthy Aminos products are for research use only.
Related Terms
Neuropeptide
A peptide that acts as a signaling molecule in the nervous system, influencing neural communication and neuromodulation.
Bioactive Peptide
A peptide that exerts a measurable effect on biological systems, as demonstrated in published research models.
NAD+ (Nicotinamide Adenine Dinucleotide)
An essential coenzyme found in all living cells, functioning as an electron carrier in metabolic reactions and a cofactor for sirtuin and PARP enzymes.
Research Use Only
FOR RESEARCH USE ONLY. Products sold by Healthy Aminos are intended strictly for in-vitro research and laboratory use. Not for human or animal consumption. Not FDA approved. By purchasing from Healthy Aminos, the buyer acknowledges that these products are not intended to diagnose, treat, cure, or prevent any disease. All products are sold as reference standards and research chemicals only.