Biological Mechanisms

Growth Hormone Secretagogue

Growth hormone secretagogues (GHS) are compounds that stimulate growth hormone (GH) release from the anterior pituitary by activating the growth hormone secretagogue receptor 1a (GHS-R1a), also known as the ghrelin receptor.

GHS compounds operate through a different mechanism than GHRH — they bind the ghrelin receptor rather than the GHRH receptor. This provides an independent pathway for GH stimulation.

Ipamorelin is characterized as a selective GHS. Published research by Raun et al. (1998, PMID: 9849822) demonstrated that ipamorelin stimulates GH release without significantly elevating cortisol, prolactin, or ACTH — distinguishing it from earlier, less selective GHS compounds.

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