GIP Receptor
The GIP receptor (GIPR) is a class B GPCR activated by glucose-dependent insulinotropic polypeptide. It is expressed on pancreatic beta cells, adipose tissue, and bone. GIPR signaling complements GLP-1R through a parallel but distinct incretin pathway.
Tirzepatide was designed as a dual GIP/GLP-1 receptor agonist, with primary activity at GIPR and secondary cross-reactivity at GLP-1R. Retatrutide engages GIPR as one of its three receptor targets (alongside GLP-1R and glucagon receptor).
Published research in the SURMOUNT clinical trial program has examined the metabolic effects of dual GIPR/GLP-1R engagement.
All Healthy Aminos products are for research use only.
Related Products
Related Terms
GLP-1 Receptor
A class B G-protein coupled receptor activated by glucagon-like peptide-1 and its analogs, central to incretin signaling research.
Incretin Effect
The enhanced insulin secretion observed when glucose is delivered orally versus intravenously, mediated by GLP-1 and GIP hormones.
Receptor Agonist
A molecule that binds to and activates a receptor, mimicking the action of the natural ligand to initiate a signaling response.
Research Use Only
FOR RESEARCH USE ONLY. Products sold by Healthy Aminos are intended strictly for in-vitro research and laboratory use. Not for human or animal consumption. Not FDA approved. By purchasing from Healthy Aminos, the buyer acknowledges that these products are not intended to diagnose, treat, cure, or prevent any disease. All products are sold as reference standards and research chemicals only.