GHRH
Growth Hormone-Releasing Hormone (GHRH) is a 44-amino-acid hypothalamic peptide that stimulates growth hormone secretion from anterior pituitary somatotroph cells by binding the GHRH receptor (GHRH-R) and activating cAMP/PKA signaling.
Tesamorelin is a synthetic GHRH analog consisting of the full 44-amino-acid human GHRH sequence with a trans-3-hexenoic acid N-terminal modification that protects against enzymatic degradation. It is the only GHRH analog to have received FDA approval (Egrifta).
GHRH-based compounds operate through a different mechanism than ghrelin-receptor-based secretagogues (like ipamorelin). GHRH stimulates pulsatile GH release while maintaining the natural secretory pattern.
All Healthy Aminos products are for research use only.
Related Products
Related Terms
Growth Hormone Secretagogue
A compound that stimulates growth hormone release by activating the ghrelin receptor (GHS-R1a) on pituitary somatotrophs.
Receptor Agonist
A molecule that binds to and activates a receptor, mimicking the action of the natural ligand to initiate a signaling response.
Half-Life
The time required for the concentration of a compound to decrease by 50%, a key pharmacokinetic parameter in peptide research.
N-Terminus
The end of a peptide chain with a free amino group (-NH2), conventionally written as the first residue in a sequence.
Research Use Only
FOR RESEARCH USE ONLY. Products sold by Healthy Aminos are intended strictly for in-vitro research and laboratory use. Not for human or animal consumption. Not FDA approved. By purchasing from Healthy Aminos, the buyer acknowledges that these products are not intended to diagnose, treat, cure, or prevent any disease. All products are sold as reference standards and research chemicals only.