Research & Regulatory

Copper Peptide

Copper peptides are peptide-metal complexes in which a copper(II) ion is coordinated to the peptide backbone, typically through histidine and amino terminal nitrogen atoms. GHK-Cu (glycyl-L-histidyl-L-lysine:copper(II)) is the most extensively studied copper peptide.

GHK-Cu was first identified in human plasma by Dr. Loren Pickart in 1973. The copper ion is essential to the complex's molecular activity. Plasma levels of GHK-Cu have been observed to decline with age. Pickart & Margolina (2018) reviewed evidence suggesting GHK-Cu modulates expression of over 4,000 human genes in cell culture models.

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Research Use Only

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