C-Terminus
The C-terminus (carboxyl terminus) is the end of a peptide chain bearing a free alpha-carboxyl group (-COOH). It is the last residue listed in conventional peptide notation. For BPC-157, the C-terminal residue is valine (Val).
C-terminal amidation — replacing the free carboxyl group with an amide group (-CONH2) — is a common modification in synthetic peptides. Amidation can increase resistance to carboxypeptidase degradation and may influence receptor binding. Ipamorelin, for example, has a C-terminal amide group (Lys-NH2).
In solid-phase peptide synthesis, the C-terminal amino acid is the first residue attached to the resin, and the chain is built from C-terminus to N-terminus — the reverse of the conventional reading direction.
All Healthy Aminos products are for research use only.
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Related Terms
N-Terminus
The end of a peptide chain with a free amino group (-NH2), conventionally written as the first residue in a sequence.
Amino Acid Sequence
The linear order of amino acid residues in a peptide or protein chain, written from N-terminus to C-terminus, which determines the molecule's identity and properties.
Amidation
The conversion of a peptide's C-terminal carboxyl group to an amide group (-CONH2), often increasing stability and receptor binding.
Research Use Only
FOR RESEARCH USE ONLY. Products sold by Healthy Aminos are intended strictly for in-vitro research and laboratory use. Not for human or animal consumption. Not FDA approved. By purchasing from Healthy Aminos, the buyer acknowledges that these products are not intended to diagnose, treat, cure, or prevent any disease. All products are sold as reference standards and research chemicals only.