Research Comparison
Tesamorelin vs Ipamorelin: GHRH vs GHS Receptor Comparison
Tesamorelin and ipamorelin both stimulate growth hormone release but through entirely different receptor mechanisms. Tesamorelin is a GHRH receptor agonist, while ipamorelin is a ghrelin receptor (GHS-R1a) agonist.
Mechanism Comparison
Tesamorelin is a 44-amino-acid GHRH analog with a trans-3-hexenoic acid N-terminal modification. It activates the GHRH receptor on pituitary somatotrophs. Falutz et al. (2010, PMID: 20554713) reported a −15.4% reduction in visceral adipose tissue in a phase 3 RCT.
Ipamorelin is a 5-amino-acid selective GHS-R1a agonist. Raun et al. (1998, PMID: 9849822) demonstrated it stimulates GH release without significantly affecting cortisol, prolactin, or ACTH — making it one of the most selective ghrelin mimetics studied.
Frequently Asked Questions
What is the difference between tesamorelin and ipamorelin?+
Research Use Only
FOR RESEARCH USE ONLY. Products sold by Healthy Aminos are intended strictly for in-vitro research and laboratory use. Not for human or animal consumption. Not FDA approved. By purchasing from Healthy Aminos, the buyer acknowledges that these products are not intended to diagnose, treat, cure, or prevent any disease. All products are sold as reference standards and research chemicals only.