Research Comparison

TB-500 vs GHK-Cu: Regenerative Peptide Research Comparison

TB-500 and GHK-Cu are both studied in the context of tissue remodeling but have fundamentally different molecular structures. TB-500 is a 43-amino-acid actin-binding peptide, while GHK-Cu is a copper-complexed tripeptide.

Property
TB-500
GHK-Cu
Amino Acids
43
3 (+ Cu²⁺)
MW
4,921 Da
403.93 Da
CAS
77591-33-4
49557-75-7
Metal Cofactor
None
Copper (Cu²⁺)
Key Domain
LKKTET (actin binding)
Gly-His-Lys:Cu²⁺ complex
Clinical Stage
Phase 2 (cardiac, dermal)
Preclinical

Structure and Mechanism

TB-500 (MW 4921 Da) operates through G-actin sequestering via the LKKTET domain. Malinda et al. (1999, PMID: 10469335) observed 42-61% increases in re-epithelialization in wound models.

GHK-Cu (MW 403.93 Da) is copper-dependent and has been studied for gene expression modulation. Pickart & Margolina (2018, PMID: 29986520) reviewed evidence that it modulates expression of over 4,000 human genes in cell culture models.

Frequently Asked Questions

What is the difference between TB-500 and GHK-Cu?+
TB-500 is a 43-amino-acid peptide that interacts with the actin cytoskeleton (MW 4921 Da). GHK-Cu is a copper-bound tripeptide studied for gene expression modulation (MW 404 Da). They differ dramatically in size, mechanism, and clinical development stage.

Research Use Only

FOR RESEARCH USE ONLY. Products sold by Healthy Aminos are intended strictly for in-vitro research and laboratory use. Not for human or animal consumption. Not FDA approved. By purchasing from Healthy Aminos, the buyer acknowledges that these products are not intended to diagnose, treat, cure, or prevent any disease. All products are sold as reference standards and research chemicals only.