Research Comparison

Semax vs Selank: Two Neuropeptide Research Compounds Compared

Semax and selank are both synthetic peptides developed at the Institute of Molecular Genetics of the Russian Academy of Sciences. Despite being developed in the same laboratory, they derive from different parent molecules and have distinct molecular targets.

Property
Semax
Selank
Amino Acids
7
7
MW
813.97 Da
751.87 Da
Parent Molecule
ACTH(4-10)
Tuftsin
CAS
80714-61-0
129954-34-3
Research Focus
BDNF/NGF, cognitive models
GABA modulation, immune function

Molecular Origins

Semax is a 7-amino-acid analog of the ACTH(4-10) fragment (Met-Glu-His-Phe-Pro-Gly-Pro, MW 813.97 Da). It retains neurotropic properties without adrenocorticotropic activity. Dolotov et al. (2006, PMID: 16996037) observed BDNF upregulation in hippocampal tissue.

Selank is a 7-amino-acid analog of tuftsin (Thr-Lys-Pro-Arg) with a Pro-Gly-Pro extension for metabolic stability (MW 751.87 Da). Zozulia et al. (2008, PMID: 18454096) conducted a human RCT comparing its anxiolytic profile.

Frequently Asked Questions

What is the difference between semax and selank?+
Semax derives from the ACTH(4-10) fragment and has been studied for BDNF modulation. Selank derives from tuftsin and has been studied for GABAergic modulation. Both are heptapeptides but have different parent molecules, sequences, and research profiles.

Research Use Only

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