Research Comparison
Epithalon vs NAD+: Telomerase vs Sirtuin Research Compounds
Epithalon and NAD+ are both studied in the context of aging research but through different molecular mechanisms. Epithalon has been investigated for its effects on telomerase activation, while NAD+ is studied as a sirtuin cofactor.
Research Context
Epithalon (Ala-Glu-Asp-Gly, MW 390.35 Da) is a synthetic tetrapeptide studied by Khavinson et al. (2003, PMID: 12937682) for its effects on telomerase (hTERT) activation in human somatic cells. Khavinson et al. (2004, PMID: 15455129) reported that treated cell cultures exceeded the Hayflick limit by approximately 10 additional passages.
NAD+ (MW 663.43 Da) declines with age in multiple tissues. Its role as the essential cofactor for SIRT1-7 deacylases links it to DNA repair, metabolic regulation, and stress response pathways. Kim et al. (2023, PMID: 36797393) conducted an NMN supplementation RCT.
Frequently Asked Questions
What is the difference between epithalon and NAD+?+
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