Compound Profiles
KPV Tripeptide: Published Research on an Alpha-MSH Fragment
Healthy Aminos Research Team · · 6 min read
Molecular Profile
[KPV](/peptides/healing/kpv) is a naturally occurring tripeptide consisting of Lys-Pro-Val, derived from the C-terminal end of alpha-melanocyte-stimulating hormone (α-MSH, positions 11-13). MW: 342.43 Da (CAS: 67727-97-3).
KPV retains certain properties of the parent α-MSH molecule while lacking melanogenic (pigmentation) activity. This makes it of particular interest in research examining inflammatory pathway modulation independent of melanocortin receptor-mediated melanogenesis.
Published Research
### NF-κB Pathway
[Dalmasso et al. (2008)](https://pubmed.ncbi.nlm.nih.gov/18061177/) examined KPV in cell culture and mouse colitis models. The study reported that KPV was associated with inhibition of NF-κB nuclear translocation — a key step in inflammatory signaling cascades. The in vivo component used dextran sodium sulfate (DSS) colitis models in mice.
### Targeted Delivery Systems
[Xiao et al. (2017)](https://pubmed.ncbi.nlm.nih.gov/28143741/) developed a nanoparticle delivery system for KPV and examined its effects in murine colitis models. The study reported that nanoparticle-encapsulated KPV showed enhanced delivery to target tissues compared to free peptide in the animal model.
### Corneal Model
[Bonfiglio et al. (2006)](https://pubmed.ncbi.nlm.nih.gov/16965771/) examined alpha-MSH-related peptides including KPV in a rabbit corneal wound model. The study assessed epithelial healing rates and inflammatory markers in treated versus control eyes.
Research Status
KPV research is primarily preclinical, spanning cell culture and animal models. The compound's small size (3 amino acids) gives it favorable stability characteristics compared to larger peptides. It is not FDA-approved.
KPV is available in 10mg vials with ≥98% purity. Also explore [BPC-157](/peptides/healing/bpc-157) and [TB-500](/peptides/healing/tb-500) in the Healing & Recovery category.
*All Healthy Aminos products are for research use only. Not for human or animal consumption. Not FDA approved.*
Research Use Only
FOR RESEARCH USE ONLY. Products sold by Healthy Aminos are intended strictly for in-vitro research and laboratory use. Not for human or animal consumption. Not FDA approved. By purchasing from Healthy Aminos, the buyer acknowledges that these products are not intended to diagnose, treat, cure, or prevent any disease. All products are sold as reference standards and research chemicals only.